esmGFP: AI Simulates 500 Million Years of Evolution to Create Novel Protein

Researchers at EvolutionaryScale and the Arc Institute have developed esmGFP, a green fluorescent protein designed entirely by the AI model ESM3. By simulating 500 million years of molecular evolution, the AI created a protein that does not exist in nature but functions effectively in laboratory settings. This breakthrough demonstrates AI’s potential in bioengineering and synthetic biology.